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Related Experiment Videos

[CNS metastases in malignant melanomas]

J Willner1, W Bohndorf

  • 1Klinik und Poliklinik für Strahlentherapie, Universität Würzburg.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|March 1, 1995
PubMed
Summary

Prognosis for malignant melanoma brain metastases is poor, with extracerebral metastases and age being key negative prognostic factors. Radiotherapy, particularly whole brain irradiation, shows potential for patient selection and treatment planning.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Research

Background:

  • Malignant melanoma can metastasize to the brain, significantly impacting patient prognosis.
  • Understanding treatment outcomes and prognostic factors is crucial for managing brain metastases.

Purpose of the Study:

  • To evaluate treatment results for patients with brain metastases from malignant melanoma.
  • To identify prognostic subgroups influencing survival in these patients.

Main Methods:

  • Retrospective analysis of 30 patients treated with whole brain irradiation (20-46 Gy) and local boosts (20-25 Gy) between 1985-1993.
  • Survival rates were compared using Cox-method, with univariate and multivariate analyses performed.

Main Results:

  • 20% of patients diagnosed with brain metastases at primary melanoma diagnosis; 83% developed within 5 years.
  • Overall 6-month survival was 39%, 1-year survival was 23%.
  • Extracerebral metastases, age, and surgical resection were significant prognostic factors; treatment time over 3 weeks worsened survival.

Conclusions:

  • Prognosis for malignant melanoma brain metastases is generally unfavorable.
  • Identified prognostic factors aid in selecting appropriate therapies, including radiosurgery.
  • A 13x3 Gy/3 weeks whole brain irradiation schedule is safe and well-tolerated.

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