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[Can vasomotion be modified by vasoactive substances or hemodilution?]
R Tischler1, M Decrinis, R Skursky-Roller
1Klinischen Abteilung für Angiologie, Medizinischen Universitätsklinik Graz.
Acta Medica Austriaca
|January 1, 1994
Summary
This study investigated how medications affect vasomotion, the control of blood vessel diameter. Buflomedil significantly influenced vasomotion in healthy tissue, suggesting potential for treating reduced blood flow.
Area of Science:
- Physiology
- Pharmacology
- Microcirculation
Background:
- Local tissue perfusion relies on vasomotion, the constriction and relaxation of microscopic blood vessels.
- Disruptions in homeostasis are compensated by vasomotion, but excessive vasomotion can lead to tissue damage.
- Reactivating vasomotion is a key therapeutic strategy for peripheral arterial insufficiency.
Purpose of the Study:
- To investigate the effects of conservative therapeutic strategies on vasomotion.
- To assess the influence of buflomedil and alprostadil on capillary blood cell velocity in normal perfused tissue.
Main Methods:
- Pilot study utilizing dynamic capillaroscopy.
- Observation of normal perfused areas in the finger nailfold.
- Administration of buflomedil, alprostadil, and hydroxyethylstarch.
Main Results:
- Buflomedil and alprostadil significantly influenced capillary blood cell velocity.
- Vasomotion was susceptible to hydroxyethylstarch and alprostadil.
- Buflomedil demonstrated a significant influence on vasomotion.
Conclusions:
- Buflomedil significantly impacted vasomotion in healthy finger nailfold capillaries.
- Further research is needed to determine if these effects translate to ischemic tissues.
- The study highlights the potential of buflomedil in managing conditions related to impaired vasomotion.