Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Anti-inflammatory effect of triptolide]

Y L Zheng1, J F Lin, C C Lin

  • 1Department of Pharmacology, Fujian Institute of Medical Sciences, Fuzhou, China.

Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway.

Circulation·1997
Same author

Higher-order organization of subrepeats and the evolution of cervid satellite I DNA.

Journal of molecular evolution·1997
Same author

Pharmacokinetics of intramuscularly administered isepamicin in man.

Chemotherapy·1997
Same author

Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation.

Cancer letters·1997
Same author

Double mycotic aneurysms of the ascending aorta.

The Annals of thoracic surgery·1997
Same author

Evaluation of four prescriptions of traditional Chinese medicine: syh-mo-yiin, guizhi-fuling-wan, shieh-qing-wan and syh-nih-sann on experimental acute liver damage in rats.

Journal of ethnopharmacology·1997

Triptolide (Tri) from Tripterygium wilfordii exhibits anti-inflammatory effects by reducing swelling and vascular permeability. High doses may stimulate the pituitary-adrenal axis in rats.

Area of Science:

  • Pharmacology
  • Natural Products
  • Immunology

Context:

  • Tripterygium wilfordii Hook f. is a traditional Chinese herb.
  • Triptolide (Tri) is a key active compound isolated from this plant.
  • Inflammation is a complex biological response involving vascular permeability and swelling.

Purpose:

  • To investigate the anti-inflammatory and immunosuppressive effects of Triptolide.
  • To explore the mechanism of action of Triptolide, particularly its effect on the pituitary-adrenal axis.

Summary:

  • Triptolide demonstrated significant inhibition of vascular permeability and swelling in rodent models induced by acetic acid, carrageenan, and formaldehyde.
  • The compound also suppressed granuloma formation but showed reduced efficacy in adrenalectomized rats, suggesting a role for adrenal function.

Related Experiment Videos

  • High-dose Triptolide administration led to thymus atrophy and stimulated the pituitary-adrenal axis without affecting prostaglandin E levels.

    • Impact:

    • These findings highlight Triptolide's potent anti-inflammatory properties and suggest its potential therapeutic applications.
    • The study provides insights into the mechanism of Triptolide's action, involving the pituitary-adrenal axis, which warrants further investigation for drug development.