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Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species
H Scheiblauer1, A P Kendal, R Rott
1Institut für Virologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
Archives of Virology
|January 1, 1995
Abstract:
Increases in infectiousness, neurotropism and virulence were found in a laboratory variant of influenza A/Seal/Massachussets/1/80 (H7N7) virus having a highly cleavable hemagglutinin. Sequential passage from host to host further increased pathogenicity of the H7N7 virus in mice, ferrets and rats.