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Renal cell carcinoma: prognostic factors
J U Roosen1, U Engel, R H Jensen
1Department of Urology, Bispebjerg Hospital, University of Copenhagen, Denmark.
British Journal of Urology
|August 1, 1994
Summary
Simple indicators like ESR and alkaline phosphatase levels, along with tumor grade and necrosis, significantly predict survival in renal cell carcinoma (RCC) patients. These factors are crucial for understanding RCC prognosis.
Area of Science:
- Oncology
- Urology
- Pathology
Background:
- Renal cell carcinoma (RCC) is a significant health concern.
- Accurate prognostic indicators are vital for patient management and treatment planning.
Purpose of the Study:
- To determine the prognostic significance of various pre-operative, per-operative, and histopathological parameters in renal cell carcinoma (RCC).
Main Methods:
- A retrospective analysis of 76 RCC patients diagnosed between 1980-1984.
- Evaluation of erythrocyte sedimentation rate (ESR), alkaline phosphatase, histological tumor grade, necrosis, and tumor vessel presence against actuarial survival.
Main Results:
- ESR, alkaline phosphatase, histological tumor grade, necrosis degree, and tumor vessel presence on angiography significantly impacted actuarial survival (P < 0.05).
- Macroscopic and microscopic tumor demarcation, vascular density, and tumor diameter did not show significant prognostic value.
Conclusions:
- Simple, reliable diagnostic indicators are essential for assessing renal cell carcinoma patient outcomes.
- ESR, alkaline phosphatase, tumor grade, necrosis, and angiography-assessed vascularity are key prognostic factors for RCC.