Related Experiment Videos
Trace element content in breasts with fibrocystic disease
G D Kanias1, E Kouri, H Arvaniti
1Radioanalytical Laboratory, N.C.S.R. DEMOKRITOS, Athens, Greece.
Biological Trace Element Research
|January 1, 1994
Summary
Trace element levels, including antimony and zinc, were higher in fibroadenoma tumors compared to fibrocystic breast disease tissue. This finding aids in understanding breast tissue composition differences.
Area of Science:
- Oncology
- Biochemistry
- Medical Physics
Background:
- Fibrocystic breast disease and fibroadenoma are common benign breast conditions.
- Trace elements play crucial roles in cellular functions and can be altered in disease states.
Purpose of the Study:
- To quantify and compare trace element concentrations in fibrocystic breast disease and fibroadenoma tissues.
- To investigate potential correlations between histological lesions and trace element levels in fibrocystic disease.
Main Methods:
- Instrumental neutron activation analysis (INAA) was employed to determine concentrations of antimony, bromine, cesium, cobalt, iron, rubidium, scandium, strontium, and zinc.
- Histological examination of fibrocystic breast disease samples was performed.
- Statistical analysis was conducted to compare element levels between disease types and correlate elements with histological findings.
Main Results:
- Mean values for several trace elements were significantly higher in fibroadenoma tumors than in fibrocystic disease tissues.
- Statistical analysis revealed specific patterns and correlations between certain trace elements and histological lesions in fibrocystic disease.
Conclusions:
- Trace element profiles differ between fibroadenoma and fibrocystic breast disease.
- The findings suggest that altered trace element concentrations may be associated with benign breast pathologies.