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Related Experiment Videos

Determination of trace elements in human lung samples

S O Rogero1, M Saiki, P H Saldiva

  • 1Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP Radiochemistry Division, São Paulo, Brazil.

Biological Trace Element Research
|January 1, 1994
PubMed
Summary
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Instrumental neutron activation analysis (INAA) quantified elements in lung tissues from smokers and nonsmokers. Results revealed differences in elemental concentrations between groups, highlighting INAA

Area of Science:

  • Environmental Science
  • Analytical Chemistry
  • Toxicology

Background:

  • Cigarette smoking significantly impacts lung health.
  • Elemental composition of lung tissue can serve as a biomarker for exposure.
  • Instrumental Neutron Activation Analysis (INAA) is a sensitive technique for elemental quantification.

Purpose of the Study:

  • To compare elemental concentrations in lung tissues of smokers versus nonsmokers using INAA.
  • To evaluate the distribution of elements in pulmonary tissue and lymph nodes.
  • To assess the precision and accuracy of the INAA method for lung tissue analysis.

Main Methods:

  • Autopsy-obtained lung tissue and lymph node samples were homogenized, lyophilized, and sterilized.
  • Samples underwent short and long irradiations in a nuclear reactor.

Related Experiment Videos

  • Gamma-ray activities were measured using Ge(Li) or hyperpure Ge detectors.

    • Main Results:

    • Elemental concentrations were determined in pulmonary tissues and hilum lymph nodes.
    • Comparisons revealed distinct elemental profiles between smokers and nonsmokers.
    • Precision and accuracy were validated using replicate analyses and reference materials.

    Conclusions:

    • INAA effectively differentiates elemental profiles in lung tissues based on smoking status.
    • Elemental analysis provides insights into the biological impact of smoking.
    • The study validates INAA as a reliable method for lung tissue elemental analysis.