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Use of total reflection X-ray fluorescence analysis in the life sciences
1Atominstitute, Austrian Universities, Vienna.
Biological Trace Element Research
|January 1, 1994
Summary
Total Reflection X-ray Fluorescence Analysis (TXRF) is a powerful elemental analysis technique. It offers simultaneous detection of most elements with high sensitivity for medium Z elements, particularly in solutions.
Area of Science:
- Analytical Chemistry
- Materials Science
- Spectroscopy
Background:
- Total Reflection X-ray Fluorescence (TXRF) is an established analytical method.
- It utilizes energy-dispersive X-ray detection with excitation under total reflection conditions.
- TXRF is known for its capability to detect a wide range of chemical elements.
Purpose of the Study:
- To highlight the capabilities of Total Reflection X-ray Fluorescence Analysis.
- To discuss its application in various scientific fields.
- To outline the requirements for analyzing different sample types.
Main Methods:
- Energy-dispersive X-ray fluorescence spectroscopy.
- Sample excitation using total reflection geometry.
- Optimization of excitation conditions for enhanced sensitivity.
Main Results:
- Simultaneous detection of nearly all chemical elements is achievable.
- Low detection limits, in the few hundred femtogram range, are possible for medium Z elements.
- Aqueous and acidic solutions are ideal sample matrices for TXRF analysis.
Conclusions:
- TXRF is a versatile and sensitive analytical technique.
- It has significant applications in life sciences due to its suitability for solution samples.
- Specialized sample preparation is necessary for solid and other complex matrices.