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Glucose administration does not modulate prolactin response to exercise, TRH or haloperidol injection
Physiological Research
|January 1, 1994
Summary
Hyperglycemia, or high blood sugar, does not affect stimulated prolactin secretion in healthy men. This study found no significant difference in prolactin levels during stimulated tests with or without high glucose levels.
Area of Science:
- Endocrinology
- Neuroendocrinology
- Human Physiology
Background:
- In vitro studies suggest glucose regulates prolactin secretion.
- The in vivo effect of hyperglycemia on stimulated prolactin release in humans remains unclear.
Purpose of the Study:
- To investigate the impact of induced hyperglycemia on prolactin release during various physiological and pharmacological stimulations in healthy males.
Main Methods:
- Healthy male volunteers underwent three standardized stimulation tests: submaximal exercise, TRH stimulation, and haloperidol administration.
- Glucose (100g) or water was administered 30 minutes prior to each test.
- Blood samples were collected to measure plasma glucose and prolactin concentrations.
Main Results:
- All applied stimuli significantly increased plasma prolactin concentrations.
- There was no significant difference in the magnitude of prolactin increase between tests performed under hyperglycemic conditions versus normoglycemic conditions (after water administration).
Conclusions:
- Hyperglycemia does not modulate prolactin release in response to various stimuli in healthy men.
- These findings suggest that glucose levels do not play a significant role in the regulation of stimulated prolactin secretion in humans.