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Ascorbic acid and fertility

M R Luck1, I Jeyaseelan, R A Scholes

  • 1Department of Physiology & Environmental Science, University of Nottingham, Leicestershire, United Kingdom.

Biology of Reproduction
|February 1, 1995
PubMed
Summary
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Ascorbic acid, also known as vitamin C, plays a crucial role in reproductive health by supporting collagen synthesis, hormone production, and antioxidant defense in both ovaries and testes. Further research into its clinical applications for infertility is warranted.

Area of Science:

  • Reproductive Biology
  • Nutritional Science
  • Biochemistry

Background:

  • Ascorbic acid (vitamin C) is linked to fertility, but its precise mechanisms in reproductive tissues are not fully understood.
  • The gonads (ovary and testis) accumulate ascorbate, suggesting a significant physiological role.
  • Reproductive processes involve tissue remodeling and hormone secretion, potentially influenced by ascorbic acid.

Purpose of the Study:

  • To explore the mechanisms by which ascorbic acid influences reproductive functions.
  • To review the roles of collagen synthesis, hormone production, and antioxidant activity of ascorbic acid in gonadal physiology.
  • To present preliminary data on ascorbic acid levels in women undergoing in vitro fertilization.

Main Methods:

  • Review of existing literature on ascorbic acid's functions in relation to reproductive tissues (ovary and testis).

Related Experiment Videos

  • Analysis of ascorbic acid's roles in collagen synthesis, hormone production, and free radical protection.
  • Presentation of preliminary data on serum and follicular fluid ascorbic acid concentrations in women undergoing IVF.

    • Main Results:

    • Ascorbic acid's functions in collagen synthesis, hormone production, and antioxidant defense are proposed as key mechanisms for its reproductive actions.
    • Both ovarian and testicular tissues exhibit ascorbate-dependent processes like remodeling and secretion.
    • Preliminary data suggest ovarian ascorbic acid supply may limit follicle growth during gonadotropin stimulation.

    Conclusions:

    • Ascorbic acid is a vital compound in gonadal physiology requiring further investigation.
    • Reappraisal of ascorbic acid's clinical utility in treating male and female infertility is timely.
    • Ascorbate's antioxidant properties may protect gametes from damage during production and fertilization.