Related Experiment Videos
Amino acids that specify structure through hydrophobic clustering and histidine-aromatic interactions lead to
N R Graciani1, K Y Tsang, S L McCutchen
1Department of Chemistry, Texas A&M University, College Station 77843-3255.
Bioorganic & Medicinal Chemistry
|September 1, 1994
Abstract:
Acyclic beta-sheet structure can be nucleated in heptapeptides when the 4-(2-aminoethyl)-6-dibenzofuranpropanoic acid residue (1) is flanked in sequence by two His residues, a His residue and a hydrophobic residue or by two hydrophobic residues. Acyclic beta-sheet peptidomimetics having an appropriate sequence have sufficient structural integrity to exhibit antimicrobial activity equivalent to that of gramicidin S.