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Antineutrophil cytoplasmic antibody-positive sera inhibit candidacidal activity of granulocytes
J Bartůnková1, T Fucíková, V Tesar
1Department of Clinical Immunology, Charles University, Prague, Czech Republic.
Experimental Nephrology
|January 1, 1995
Abstract:
Antineutrophil cytoplasmic antibodies (ANCA) are suspected of being involved in the pathogenesis of tissue injury in systemic vasculitis. We have investigated the effect of 10 sera from 8 patients with ANCA-associated diseases on the capacity of neutrophils derived from healthy persons to kill ingested Candida albicans. ANCA-containing sera inhibited candidacidal activity by 55-80% in comparison to control sera. This phenomenon could lead to the depression of antimicrobial resistance of patients with ANCA and could be involved in the pathogenesis of granuloma formation.