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Cell surface adhesion receptors

G Wagner1, D F Wyss

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

Current Opinion in Structural Biology
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

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Recent advances reveal novel structural motifs in cell surface adhesion receptors and their complexes. This review covers new insights into glycoprotein domains and receptor-ligand interactions.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Cell Biology

Background:

  • Cell surface adhesion receptors mediate crucial cellular processes.
  • Understanding their structure is key to deciphering cell-cell interactions.

Purpose of the Study:

  • To review recent structural findings in cell adhesion receptors.
  • To highlight new insights into receptor-ligand complexes and glycoprotein structures.

Main Methods:

  • Analysis of recently published structural data.
  • Review of proposed structural models for receptor complexes.
  • Examination of studies on carbohydrate conformation in glycoproteins.

Main Results:

  • Discovery of novel structural motifs in adhesion receptors.

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  • Elucidation of two-domain structures of extracellular receptor portions.
  • Development of structural models for receptor-counter-receptor complexes.
  • First reports on carbohydrate conformation within intact glycoprotein domains.

    • Conclusions:

    • Significant progress has been made in understanding the structure of cell adhesion receptors.
    • New structural data provide a foundation for future research into cell adhesion mechanisms.