Domain movements in protein kinases
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S Cox1, E Radzio-Andzelm, S S Taylor
1Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093-0654.
Current Opinion in Structural Biology
|December 1, 1994
Abstract:
Structural studies of the catalytic subunit of the cAMP-dependent protein kinase, both by crystallographic methods and in solution, reveal two conformations. Crystal structures of several other protein kinases have also been solved in the past year. With this combined information we can begin to define mobile domains and subdomains within the conserved catalytic core.