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Phytate and zinc bioavailability

A Wise1

  • 1School of Food and Consumer Studies, Robert Gordon University, Aberdeen.

International Journal of Food Sciences and Nutrition
|February 1, 1995
PubMed
Summary
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Dietary phytate can reduce zinc absorption in humans, influenced by calcium and protein. Further research is needed to confirm if animal study findings on phytate-zinc interactions apply to human dietary recommendations.

Area of Science:

  • Nutritional Science
  • Human Physiology

Background:

  • Dietary phytate is known to inhibit zinc absorption.
  • Calcium and magnesium can potentiate phytate's effect by forming precipitates with zinc.
  • Dietary protein may improve zinc bioavailability by interacting with these precipitates.

Purpose of the Study:

  • To review human studies on the impact of dietary phytate on zinc bioavailability.
  • To assess the applicability of animal study findings to human nutrition.
  • To identify research gaps in understanding phytate-zinc interactions in humans.

Main Methods:

  • Review of human studies examining zinc status, absorption (apparent and true), plasma tolerance, and radioisotope accumulation.
  • Analysis of factors like calcium, magnesium, and protein in relation to phytate and zinc.

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Main Results:

  • Evidence confirms detrimental effects of phytate on human zinc bioavailability.
  • The specific mechanisms and interactions observed in animal studies may not directly translate to humans.
  • Existing studies were not specifically designed to validate animal-derived predictive ratios for human use.

Conclusions:

  • Dietary phytate negatively affects zinc bioavailability in humans.
  • More targeted human research is necessary to validate predictive ratios before their application in human dietary guidelines.
  • The roles of calcium, magnesium, and protein in modulating these interactions require further investigation in human subjects.