Related Experiment Video
Updated: Oct 20, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
[Characteristics of hypoxic ventilatory response in Tibetan living at moderate and high altitudes]
Abstract:
Hypoxic and exercises ventilatory responses measured in Tibetan who lived at moderate (2000-3000m, M-Tibetan) and high (4000-4700m, H-Tibetan) altitude areas. The result showed that the slope of hypoxic ventilatory response (HVR; VE/SaO2) in M- and H-Tibetan was 0.81 +/- 0.07 and 0.46 +/- 0.04 L/min/%SaO2 (P < 0.01) and the maximal exercise ventilation (VEmax) was 78.3 +/- 3.5 and 68.2 +/- 2.1 L/min (P < 0.05), respectively. There were positive correlation between delta VE/delta SaO2 and VEmax, which gamma = 47.0 +/- 37.3x, r = 0.70 in M-Tibetan, and gamma = 53.8 +/- 31.4x, r = 0.67 in H-Tibetan. Maximal heart rate of the H-Tibetan was significantly lower than that in the M-Tibetan (P < 0.01). It is suggested that the attenuation of HVR depends on the magnitude of the hypoxic stimulus. Therefore, there are differences even among the high-altitude natives in ventilatory response to hypoxia, e.g. normal respiratory sensitivity to hypoxia in moderate-altitude natives, and blunted in high-altitude natives.
More Related Videos
09:33Using Near-Infrared Spectroscopy Wearable Devices to Identify Central Versus Peripheral Limitations During Exercise
Published on: December 19, 2024
08:41Hypercapnic Hyperventilation to Accelerate Emergence from Inhaled Volatile Anesthetics: A Practical Method Using Standard Hospital Equipment
Published on: June 26, 2026
Related Concept Videos
Factors Affecting Respiration
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
Hyperpnea and Hyperventilation
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-IV