Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary biliary cirrhosis

J M Laurin1, K D Lindor

  • 1Division of Gastroenterology, Mayo Clinic and Foundation, Rochester, Minn 55905.

Digestive Diseases (Basel, Switzerland)
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: is proton pump inhibitor use associated with worse outcomes in patients with liver abscesses?

Alimentary pharmacology & therapeutics·2018
Same author

Review article: the evidence that vancomycin is a therapeutic option for primary sclerosing cholangitis.

Alimentary pharmacology & therapeutics·2018
Same author

Editorial: Betaretrovirus in biliary epithelia of patients with autoimmune and cryptogenic liver disease.

Alimentary pharmacology & therapeutics·2015
Same author

An update on primary sclerosing cholangitis:from pathogenesis to treatment.

Minerva gastroenterologica e dietologica·2013
Same author

Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis - a pilot study.

Alimentary pharmacology & therapeutics·2013
Same author

Interactions between chronic liver disease and inflammatory bowel disease.

Inflammatory bowel diseases·2013

Primary biliary cirrhosis is an autoimmune liver disease primarily affecting women. While no cure exists, treatments like ursodeoxycholic acid and liver transplantation offer hope for managing this progressive condition.

Area of Science:

  • Hepatology
  • Autoimmunology
  • Biochemistry

Background:

  • Primary biliary cirrhosis (PBC) is a chronic, autoimmune cholestatic liver disease.
  • It predominantly affects middle-aged women and is linked to mitochondrial antibodies.
  • PBC often co-occurs with other autoimmune disorders.

Purpose of the Study:

  • To summarize the current understanding of primary biliary cirrhosis.
  • To discuss diagnostic markers and management strategies.
  • To review prognostic indicators and treatment options.

Main Methods:

  • Literature review of primary biliary cirrhosis.
  • Analysis of autoimmune associations.
  • Evaluation of therapeutic interventions and prognostic models.

Related Experiment Videos

Main Results:

  • PBC is characterized by antimitochondrial antibodies targeting pyruvate dehydrogenase complex.
  • Ursodeoxycholic acid shows promise as a treatment.
  • Fat malabsorption and vitamin deficiencies are common complications.

Conclusions:

  • Effective medical treatments for PBC are still evolving.
  • Prognosis varies significantly among patients.
  • Liver transplantation improves quality of life in advanced stages.