[Morphological and functional changes of the human vascular endothelial cells in pregnancy induced hypertension...

Normal human vascular endothelial cells were cocultured with sera from pregnancy induced hypertension (PIH) patients. After staining it was found that sera from PIH patients could induce stress fibers production from the endothelial cells and which sometime destroy the integrity of normal monolayer structure of endothelium, thus result in endothelial damage. Sera from PIH patients could also induce intracellular adhesion molecules on the cell surface, thus result in the blood cells adhesion to vascular wall, and loss of endothelial cells from vascular wall under certain condition, thereby causing endothelial damage.