[Insulin resistance and pregnancy induced hypertension]

Plasma glucose and serum insulin in oral glucose tolerance test (OGTT) were measured in 40 patients with pregnancy induced hypertension (PIH) and 30 normal pregnancies. Compared with the controls, serum insulin concentration, plasma glucose and their area under the curve (AUC) increased in 15 patient with severe PIH, in 0.5, 1, 2, 3 hours postload (P < 0.05) of OGTT. The relationship between diastolic blood pressure and integrated area under the curve for serum insulin concentration (r = 0.35, P < 0.05) were observed in 15 patients with severe PIH. The results indicated that patients with severe PIH are insulin resistant and hyperinsulinemic after an oral glucose load.