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Variation in selenoprotein P concentration in serum from different European regions
E Marchaluk1, M Persson-Moschos, E B Thorling
1Department of Applied Nutrition and Food Chemistry, University of Lund, Sweden.
European Journal of Clinical Nutrition
|January 1, 1995
Summary
Serum selenoprotein P levels vary significantly across European regions and countries in healthy adults. These geographical differences in selenoprotein P concentration and its relation to selenium require further investigation.
Area of Science:
- Human Health
- Nutritional Science
- Biochemistry
Background:
- Selenoprotein P (SeP) is a key selenium-transporting protein in human serum.
- Understanding geographical variations in SeP is crucial for assessing selenium status and health implications.
Purpose of the Study:
- To investigate the geographical variability of serum selenoprotein P levels.
- To compare SeP concentrations across different European regions and countries.
Main Methods:
- A survey of 414 healthy adults (aged 37-70) from 17 European regions across nine countries.
- Serum samples were analyzed for selenoprotein P concentration.
Main Results:
- Significant variations in serum selenoprotein P levels were observed among European regions and countries.
- Spain, Belgium, and the United Kingdom showed the highest mean SeP concentrations.
- A strong positive linear correlation (r=0.68) was found between serum selenium and serum selenoprotein P.
Conclusions:
- Serum selenoprotein P concentration and its proportion to total serum selenium differ geographically in European adults.
- Further research is needed to understand the physiological and medical significance of these observed variations.
