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Related Experiment Videos

Do NMDA receptor-mediated changes in motor behaviour involve nitric oxide?

M S Starr1, B S Starr

  • 1Department of Pharmacology, School of Pharmacy, London, UK.

European Journal of Pharmacology
|January 16, 1995
PubMed
Summary

Nitric oxide (NO) synthase inhibitors like NG-nitro-L-arginine suppressed normal motor behaviors in mice. Inhibition of NO synthase also reduced locomotion induced by dopamine agonists, suggesting NO is crucial for movement.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Nitric oxide (NO) plays a role in various physiological processes, including neurotransmission.
  • Understanding the role of NO in motor control is essential for neurological research.

Purpose of the Study:

  • To investigate the effects of nitric oxide (NO) synthase inhibitors on motor behavior in mice.
  • To determine the involvement of NO in dopamine-mediated motor activity.

Main Methods:

  • Administration of NO synthase inhibitors (NG-nitro-L-arginine, 7-nitroindazole, aminoguanidine) to normal and reserpine-treated mice.
  • Assessment of motor behaviors and locomotion induced by dopamine D1 and D2 receptor agonists (SKF 38393, RU 24213).

Main Results:

  • NG-nitro-L-arginine and 7-nitroindazole suppressed species-typical behaviors in normal mice.

Related Experiment Videos

  • NO synthase inhibitors did not reverse reserpine-induced akinesia but suppressed agonist-induced locomotion.
  • L-arginine partially prevented the suppression of locomotion by NO synthase inhibitors.

    • Conclusions:

    • Constitutive NO synthase activity is necessary for normal motor function.
    • NO generation is not implicated in the D1-facilitatory effect of glutamate receptor blockade on dopaminergic drugs.