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Related Experiment Videos

Myocardial edema, left ventricular function, and pulmonary hypertension

K L Davis1, U Mehlhorn, G A Laine

  • 1Department of Anesthesiology, University of Texas Medical School, Houston 77030.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1995
PubMed
Summary

Pulmonary hypertension causes left ventricular myocardial interstitial edema. This edema leads to impaired systolic and diastolic left ventricular function, as demonstrated in a canine model.

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Area of Science:

  • Cardiology
  • Physiology
  • Pathophysiology

Background:

  • Left ventricular dysfunction is a known complication of pulmonary hypertension.
  • The underlying mechanisms linking pulmonary hypertension to left ventricular dysfunction remain unclear.

Purpose of the Study:

  • To investigate the hypothesis that acute pulmonary hypertension induces left ventricular myocardial interstitial edema.
  • To determine if this edema is the cause of left ventricular dysfunction.

Main Methods:

  • Acute pulmonary hypertension was induced in dogs via pulmonary artery banding.
  • Left ventricular function was assessed using sonomicrometry and micromanometry to measure contractility (preload recruitable stroke work) and relaxation (tau).
  • Left ventricular myocardial interstitial edema was quantified by measuring wet-to-dry weight ratios.

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Main Results:

  • Pulmonary artery-banded dogs showed significantly increased left ventricular wet-to-dry weight ratios, indicating edema.
  • Contractility (PRSW) decreased significantly in dogs with pulmonary hypertension.
  • Diastolic relaxation (tau) significantly slowed in the pulmonary hypertension group.

Conclusions:

  • Acute pulmonary hypertension causes left ventricular myocardial interstitial edema.
  • This edema is responsible for the observed systolic and diastolic left ventricular dysfunction.