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Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal
I W Fong1, C B Britton, K E Luinstra
1Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.
Journal of Clinical Microbiology
|February 1, 1995
Abstract:
JC virus DNA was detected by PCR in the cerebrospinal fluid of 17 of 23 (73.9%) patients with confirmed cases of progressive multifocal leukoencephalopathy and 2 of 48 (4.2%) controls without progressive multifocal leukoencephalopathy. The sensitivity and specificity of this PCR were 74 and 95.8%, respectively, while the positive and negative predictive values were 89.5 and 88.5%, respectively.