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Gastrointestinal motility in obesity
1Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
Journal of Internal Medicine
|April 1, 1995
Summary
Obesity may alter gastrointestinal motility, leading to faster nutrient absorption and reduced satiety. Further research is needed to determine if these motility changes contribute to the development of obesity.
Area of Science:
- Gastroenterology
- Metabolism
- Obesity Research
Background:
- Gastrointestinal motility influences nutrient availability.
- Gastric emptying regulation is crucial for preventing nutrient overload.
- Obesity is associated with altered gastric emptying and nutrient absorption.
Purpose of the Study:
- To investigate the relationship between obesity and gastrointestinal motility.
- To explore the impact of altered motility on nutrient absorption and satiety in obesity.
Main Methods:
- Review of existing studies on gastric emptying, intestinal transit, and nutrient absorption in obese and normal-weight individuals.
- Examination of regulatory mechanisms of gastrointestinal motility, including nervous systems and peptides.
Main Results:
- Obesity may involve more rapid gastric emptying and larger gastric volumes.
- Nutrient absorption appears more efficient in obesity, despite similar intestinal transit times.
- Dysfunctions in the autonomous nervous system and altered peptide sensitivity (cholecystokinin, somatostatin, neurotensin) are observed in obesity.
Conclusions:
- Observed changes in gastrointestinal motility in obesity may promote rapid nutrient transit and absorption, alongside decreased satiety.
- The role of these motility changes as a primary factor in obesity pathogenesis remains unclear.