Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

p53 immunoreactivity in oligodendrogliomas

J Pavelić¹, V Hlavka, M Poljak

¹Department of Molecular Medicine, Rugjer Bosković Institute, Zagreb, Croatia.

Journal of Neuro-Oncology

|January 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Living with COPD and its psychological effects on participating in community-based physical activity in Brazil: a qualitative study. Findings from the Breathe Well group.

NPJ primary care respiratory medicine·2024

Same author

Reporting radiographers within the European Federation of Radiographer Society (EFRS) member countries - motivation for becoming a reporting radiographer.

Radiography (London, England : 1995)·2024

Same author

Validation of the clinical performance and reproducibility of the NeuMoDx HPV assay self-sample workflow.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2024

Same author

Reporting radiographers in Europe survey: Support, role satisfaction, and advanced clinical practice within the European federation of radiographer society (EFRS) member countries.

Radiography (London, England : 1995)·2023

Same author

Reporting radiographers in Europe survey: An overview of the role within the European Federation of Radiographer Society (EFRS) member countries.

Radiography (London, England : 1995)·2023

Same author

Accuracy and economic evaluation of screening tests for undiagnosed COPD among hypertensive individuals in Brazil.

NPJ primary care respiratory medicine·2022

p53 protein accumulation increases with human oligodendroglioma malignancy. High p53 expression was observed in all malignant tumors, suggesting a link to tumor progression.

Area of Science:

Neuro-oncology
Molecular Pathology
Cancer Biology

Background:

Oligodendrogliomas are primary brain tumors with varying grades of malignancy.
The p53 tumor suppressor protein plays a critical role in cellular response to DNA damage and oncogenesis.
Understanding p53 expression patterns can offer insights into oligodendroglioma progression.

Purpose of the Study:

To investigate the correlation between p53 protein accumulation and the grade of malignancy in human oligodendrogliomas.
To determine if p53 expression levels can serve as a biomarker for tumor progression.

Main Methods:

Immunohistochemistry was performed on formalin-fixed paraffin-embedded tissue sections of human oligodendrogliomas.
Monoclonal antibody PAb 1801 was used to detect p53 protein expression.

Related Experiment Videos

Tumor samples were categorized by grade (Type I, Type II, and anaplastic/malignant).

Main Results:

p53 protein accumulation was significantly correlated with tumor malignancy.
100% of malignant oligodendrogliomas showed p53 positivity.
Positivity rates were 64% for Type II and 28% for Type I oligodendrogliomas.
The proportion of reactive cells for p53 was higher in malignant tumors, though staining intensity did not vary by grade.

Conclusions:

p53 protein accumulation is directly linked to the malignant progression of human oligodendrogliomas.
Further research is needed to confirm the predictive value of p53 accumulation for oligodendroglioma behavior.