[The specific and biological action of chemical preparations and their combination with pathogenetic agents in...

The hypersensitizing effect of benzimidazole carbamates (BC), the therapy for trichinellosis, especially in heavily infected patients, determines the necessity of simultaneous administration of glucocorticoids (GC) for the prevention of severe systemic and organ-specific complications. This combination delayed the convalescent period, in severe cases it provokes coagulopathic disorders, infrequently fatal haemorrhages. The combination of BC with nonsteroidal anti-inflammatory drugs (NSAIDs) significantly shortened the convalescent period in semisevere and moderate cases of the disease along with normalized PGF and PGE production. In experimental mice and guinea pigs, the inhibition of specific T-cell responses without inhibiting their response to FGA, and the high antibody mediated cytotoxic activity after BC and NSAID therapy were found. Thus, in severe cases of the disease GC should be applied very immediately, replaced later by NSAIDs. The possible role of the biological action of BC, as donors of imidazoles in the microenvironment of muscle larvae, favoured by the poor content of natural imidazoles is discussed.