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Related Experiment Videos

[Selenium and antioxidant status in various diseases]

K Winnefeld1, W Schirrmeister, R Thiele

  • 1Institut für Klinische Chemie und Laboratoriumsdiagnostik, Jena.

Medizinische Klinik (Munich, Germany : 1983)
|January 15, 1995
PubMed
Summary

Oxidative stress disrupts antioxidant balance in disease. This study measured selenium, glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in various conditions, revealing decreased selenium and GSH-Px with increased MDA in severe illnesses, indicating lipid peroxidation.

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Area of Science:

  • Biochemistry
  • Pathophysiology
  • Clinical Chemistry

Context:

  • Mammalian health relies on antioxidant-oxidant balance.
  • Disease states often involve disturbed homeostasis and increased oxidative stress.
  • Antioxidant therapies are increasingly used to mitigate cellular damage.

Purpose:

  • To assess antioxidant status by measuring selenium, glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in patients with diverse clinical conditions.
  • To investigate the relationship between these markers and oxidant stress in various diseases.

Summary:

  • Patients with terminal renal insufficiency and septic shock exhibited decreased serum/whole blood selenium and GSH-Px activity, alongside elevated serum MDA, indicative of heightened lipid peroxidation.
  • High-risk pregnancies and women on oral contraceptives showed normal GSH-Px activity but increased MDA, suggesting a compensatory antioxidant response.

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  • Preliminary selenium therapy in renal failure patients showed positive outcomes.

    • Impact:

    • Highlights the utility of selenium, GSH-Px, and MDA as biomarkers for oxidative stress and disease severity.
    • Provides insights into the complex antioxidant dynamics in different pathological states.
    • Informs potential therapeutic strategies involving antioxidant supplementation, particularly selenium.