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Nontoxic intravitreal dose of ofloxacin for rabbit retina
H Sakai1, K Mochizuki, M Torisaki
1Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan.
Ophthalmic Research
|January 1, 1994
Abstract:
We studied the nontoxic intravitreal concentration of ofloxacin, a new quinolone antibacterial agent, by evaluating its effects on in vitro and in vivo electroretinograms (ERGs) in albino and pigmented rabbits. After perfusion with a 36 micrograms/ml solution of ofloxacin, the in vitro ERG remained unchanged. The in vivo ERG and the visually evoked potential remained unchanged 4 weeks after vitrectomy with 50 micrograms/ml ofloxacin, and the retina was within normal limits both ophthalmoscopically and histologically. Therefore, the retinal toxicity of ofloxacin is low and within safe limits at clinical dosage.