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Bioactive cyclic dipeptides

C Prasad1

  • 1Department of Medicine, Louisiana State University Medical Center, New Orleans 70112, USA.

Peptides
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Cyclic dipeptides, simple natural compounds, are found in plants and animals. While some show physiological activity in mammals, their full potential as bioactive peptides remains largely unexplored.

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Area of Science:

  • Biochemistry
  • Natural Products Chemistry

Background:

  • Cyclic dipeptides are simple peptide derivatives prevalent in nature.
  • Many are by-products of fermentation and food processing, but some are endogenous to plants and animals.

Purpose of the Study:

  • To review the occurrence and potential bioactivity of cyclic dipeptides.
  • To highlight the unexplored nature of these compounds in mammalian systems.

Main Methods:

  • Literature review of cyclic dipeptides.
  • Analysis of their presence in natural sources and potential precursor relationships.

Main Results:

  • Cyclic dipeptides like cyclo(Pro-Leu) and cyclo(His-Pro) are found in various organisms.
  • Five specific cyclic dipeptides exhibit physiological/pharmacological activities in mammals.

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  • Only cyclo(His-Pro) is confirmed as endogenous to mammals; others have structural links to known peptides.

    • Conclusions:

    • Cyclic dipeptides represent a promising, yet underexplored, class of bioactive peptides.
    • Further research is needed to confirm precursor relationships and endogenous roles in mammals.