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Related Experiment Videos

[Is the intestinal transplant a reality?]

M Erbessd López1, A J Athié

  • 1Servicio de Cirugia General, Hospital General Dr. Manuel Gea González, México, D.F.

Revista De Gastroenterologia De Mexico
|July 1, 1994
PubMed
Summary

Small bowel transplantation faced challenges like rejection and technical issues. The introduction of cyclosporine and other immunosuppressants has significantly improved outcomes for patients undergoing this procedure.

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[Ileosigmoid volvulus. A case report].

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion·1989
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Area of Science:

  • Gastroenterology
  • Immunology
  • Surgical Innovation

Background:

  • Early small bowel transplantation attempts were hindered by significant immunological and technical obstacles.
  • Graft rejection and graft-versus-host disease were primary reasons for trial failures.

Purpose of the Study:

  • To review the historical challenges in small bowel transplantation.
  • To highlight the impact of immunosuppressive agents on transplant success.

Main Methods:

  • Historical review of small bowel transplantation literature.
  • Analysis of the role of immunosuppressive drugs in patient outcomes.

Main Results:

  • The advent of cyclosporine revolutionized small bowel transplantation feasibility.
  • A wide array of immunosuppressors, including prednisone, azathioprine, and newer agents like rapamycin and mycophenolate mofetil, have further enhanced patient survival.

Conclusions:

  • Immunosuppressive therapy is critical for the success of small bowel transplantation.
  • Advances in immunosuppression have transformed the prognosis for small bowel transplant recipients, overcoming previous limitations.

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