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Ossification of the posterior longitudinal ligament. Autosomal recessive trait
1Department of Orthopaedic Surgery, Kinki University School of Medicine.
Study Design:
This study analyzed the mode of inheritance of ossification of the posterior longitudinal ligament (OPLL) from the pedigree of a family.
Objectives:
The results were correlated to provide a new mode of inheritance of OPLL.
Summary Of Background Data:
Although a nation-wide multicenter survey of OPLL has been carried out in 347 subjects and 1030 relatives in Japan since 1981, no parental consanguinity has been reported.
Methods:
In the family, three siblings and one other member of a family underwent operations for OPLL in our department, and the clinical information regarding other family members was obtained from interviews with these four patients or relatives.
Results:
The parents of three affected siblings and another unaffected sister were first cousins, and the father was suspected to be affected as well.
Conclusion:
Transmission of OPLL as an autosomal recessive trait in this family, which has not been reported, is suspected; although, the possibility that it is a dominant trait can not be excluded.