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[Prolactin secretion in hyperthyroid individuals]

E Stokić1, T Ivković-Lazar, Lj Babić

  • 1Department of Endocrinology, Institute of Internal Diseases, Novi Sad.

Srpski Arhiv Za Celokupno Lekarstvo
|March 1, 1993
PubMed
Summary

Hyperthyroidism impacts prolactin secretion, showing normal baseline levels but reduced responses to stimulation and suppression tests. This suggests a diminished prolactin reserve in the pituitary gland of hyperthyroid patients.

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Neuroendocrinology

Background:

  • Hyperthyroidism is associated with various endocrine and metabolic alterations.
  • Changes in prolactin secretion are noted in hyperthyroid individuals.
  • A reduced prolactin content within secretory granules of pituitary lactotrophs (decreased prolactin pool) is a key consideration.

Purpose of the Study:

  • To investigate prolactin secretion patterns in patients with hyperthyroidism.
  • To assess the prolactin reserve in the anterior pituitary gland under hyperthyroid conditions.

Main Methods:

  • Studied prolactin secretion in 30 hyperthyroid patients.
  • Evaluated basal prolactin levels.
  • Administered stimulation tests (thyrotropin-releasing hormone and eglonylic acid tests).

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  • Conducted suppression tests (L-DOPA and bromocriptine tests).

    • Main Results:

    • Patients exhibited normoprolactinemia under basal conditions.
    • Prolactin demonstrated a blunted response during stimulation tests.
    • Prolactin secretion was also impaired during suppression tests.
    • These findings indicate a reduced prolactin pool in hyperthyroidism.

    Conclusions:

    • Hyperthyroidism is linked to a decreased prolactin pool in the pituitary gland.
    • The impaired prolactin response suggests compromised secretory capacity in lactotrophs.
    • Further research into the mechanisms underlying prolactin dysregulation in hyperthyroidism is warranted.