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[Monocytoid B-cell lymphoma: clinico-pathologic study of 2 cases]
T Alvaro1, E Contreras, J Gumá
1Servicio de Anatomía Patológica, Hospital Verge de la Cinta, Tortosa, Tarragona.
Sangre
|February 1, 1995
Summary
This study examines monocytoid B-cell lymphoma, a low-grade lymphoma typically affecting older women. Findings highlight its varied presentation and potential for aggressive behavior, impacting diagnosis and prognosis.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Monocytoid B-cell lymphoma (MBCL) is a low-grade malignant lymphoma.
- It predominantly affects elderly individuals, particularly women.
- MBCL is often diagnosed at early stages (I-II) and typically involves lymph nodes, with rare peripheral blood, bone marrow, or spleen involvement.
Observation:
- A morphologic and immunohistochemical analysis of two MBCL cases was performed.
- Both cases exhibited characteristic monocytoid B-cell morphology: homogeneous nuclei, scant mitoses, and abundant clear cytoplasm.
- Immunohistochemistry confirmed tumor cell expression of CD45, CD20, HLA-DR, and monoclonal IgM-lambda/lambda light chains.
Findings:
- Case 1 presented with irregular nuclei, prominent nucleoli, advanced-stage disease, and a rapid clinical course.
- Case 2 displayed an epithelioid granulomatous reaction, which initially obscured the diagnosis and led to delayed detection until relapse.
- These cases illustrate the diverse clinical presentations and potential for aggressive behavior in MBCL.
Implications:
- The varied clinical onset and potential for aggressive disease underscore the importance of thorough diagnostic evaluation for MBCL.
- MBCL's association with other lymphoma types necessitates careful consideration during diagnosis.
- Challenges in morphologic identification highlight the need for integrated clinicopathologic assessment.