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Decreased serum insulin-like growth factor I during puberty in children with insulin dependent diabetes mellitus

E K Normann1, U Evald, K Dahl-Jørgensen

  • 1Department of Pediatrics, Aker University Hospital, Oslo, Norway.

Upsala Journal of Medical Sciences
|January 1, 1994
PubMed

Insights

Children with insulin-dependent diabetes mellitus (IDDM) show decreased insulin-like growth factor-I (IGF-I) levels. Diabetic boys also had elevated growth hormone, and diabetic girls experienced delayed puberty markers.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Growth and Development

Background:

  • Conflicting reports exist regarding insulin-like growth factor-I (IGF-I) levels in diabetic individuals.
  • Understanding IGF-I and growth hormone in pediatric diabetes is crucial for assessing pubertal development.

Purpose of the Study:

  • To investigate serum IGF-I levels in children with insulin-dependent diabetes mellitus (IDDM) compared to healthy controls.
  • To examine the relationship between IGF-I, growth hormone, and pubertal development in pediatric diabetics.

Main Methods:

  • A cohort of 66 children (33 with IDDM, 33 controls) aged 7.1 to 19.7 years participated.
  • Serum IGF-I and growth hormone concentrations were measured.
  • Pubertal development markers, including menarche and bone maturation, were assessed.

Main Results:

  • Serum IGF-I was significantly lower in children with IDDM compared to controls (diabetic girls: 28.3 nmol/l vs. 42.8 nmol/l; diabetic boys: 30.0 nmol/l vs. 44.1 nmol/l).
  • Diabetic boys exhibited higher mean growth hormone levels than controls (3.5 µg/l vs. 1.8 µg/l).
  • Diabetic girls showed delayed menarche and slightly delayed bone maturation.

Conclusions:

  • Children with IDDM have reduced serum IGF-I levels, irrespective of sex.
  • Elevated growth hormone in diabetic boys and delayed puberty markers in diabetic girls suggest altered growth dynamics in pediatric diabetes.
  • Further research is warranted to elucidate the impact of these hormonal changes on long-term growth and development in diabetic children.

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