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[Hemocoagulation and hemorheology in heart failure and the possible effects of glycosaminoglycans]
Insights
Sulodexide treatment improved blood flow in patients with chronic heart failure by reducing clotting factors and increasing natural anticoagulants. This therapy was well-tolerated and showed no significant adverse effects.
Area of Science:
- Cardiology
- Hematology
- Pharmacology
Context:
- Chronic congestive heart failure (CHF) patients often develop hypercoagulable and hyperviscous states.
- These conditions increase risks associated with cardiovascular disease.
Purpose:
- To investigate the effects of sulodexide on coagulation and viscosity in CHF patients.
- To assess the safety and tolerability of sulodexide in this patient group.
Summary:
- Sulodexide administration in moderate to severe CHF patients enhanced fibrinolytic potential, indicated by decreased plasminogen activator inhibitor-1 (PAI-1) and fibrinogen levels.
- The treatment also boosted anticoagulatory potential, evidenced by increased antithrombin III (AT III) levels and reduced plasma viscosity.
- No significant changes were observed in global coagulation or general biochemical screening parameters.
Impact:
- Sulodexide effectively modulates the hypercoagulable and hyperviscous state associated with chronic heart failure.
- The observed improvements in fibrinolysis and anticoagulation suggest a potential therapeutic benefit for CHF patients.
- The well-tolerated nature of sulodexide indicates its suitability for clinical use in managing complications of heart failure.
Abstract:
Chronic congestive heart failure is one of the risk groups of acquired hypercoagulant and hyperviscous state. In a group of patients with medium and severe cardiac failure the administration of sulodexide led to an increased activation of the fibrinolytic potential--a drop of PAI-1 and fibrinogen, to an increased activation of anticoagulatory potential--an increase of AT III and reduced plasma viscosity. Global coagulation and biochemical screening parameters were not affected by treatment. Administration of the preparation did not exert important undesirable effects and was well tolerated.