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Comparison of dopexamine hydrochloride, fenoldopam, and procaterol on myocardial nutritional flow in rats
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|September 1, 1994
Abstract:
Myocardial nutritional flow (MNF) was determined using 99mTechnetium-methoxy-isobutyl-isonitrile (99mTc-MIBI) in rats. At 25 nmol.kg-1, dopexamine hydrochloride (DH), fenoldopam, and procaterol increased the uptake rate of 99mTc-MIBI/g myocardium by 80.8 +/- 10.2% (P < 0.01), 44.9 +/- 6.3% (P < 0.05), and 30.2 +/- 5.4% (P < 0.05) respectively. These findings suggested the potential advantages of DH over other dopaminergic agonists in the treatment of coronary disease.