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Rapid tolerance to formation of authentic NO from nitroglycerin in vivo
M G Persson1, P Agvald, L E Gustafsson
1Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Agents and Actions. Supplements
|January 1, 1995
Abstract:
Direct evidence for in vivo NO formation from nitroglycerin (GTN) was obtained by measurements of exhaled nitric oxide in anaesthetized. Infusions of GTN (1-100 micrograms kg-1 min-1 i.v.) induced dose-dependent and biphasic increments in exhaled NO parallelled by reductions in systemic blood pressure. The NO detected during GTN infusion was unaffected by the nitric oxide synthase inhibitor L-NAME or acute i.v. administration of L-cysteine, N-acetyl-L-cysteine or glutathione. The present data demonstrate that NO is formed from GTN in vivo, and that tolerance in vivo is due to decreased formation of NO.