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The effects of fibrates on lipoprotein and hemostatic coronary risk factors
1Div. Atherosclerosis, Nutrition and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63110.
Atherosclerosis
|December 1, 1994
Insights
Fibrates improve lipoprotein profiles and affect coagulation and fibrinolysis, suggesting benefits for preventing atherosclerosis. These lipid-lowering drugs offer a promising therapeutic strategy for cardiovascular health.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Biochemistry
Background:
- Atherosclerosis is a major cause of cardiovascular disease.
- Lipoprotein profiles and coagulation/fibrinolysis factors are key determinants of atherosclerosis.
- Fibrates are a class of drugs known to affect lipid metabolism.
Purpose of the Study:
- To review the effects of fibrates on lipoprotein profiles.
- To examine the impact of fibrates on lipoprotein physiology.
- To assess the influence of fibrates on coagulation and fibrinolytic factors relevant to atherosclerosis.
Main Methods:
- Literature review of studies on fibrate effects.
- Analysis of data on changes in lipoprotein levels (e.g., HDL, LDL, triglycerides).
- Evaluation of studies investigating fibrate impact on clotting and clot-dissolving factors.
Main Results:
- Fibrates significantly alter lipoprotein profiles, often increasing HDL and decreasing triglycerides.
- Changes in lipoprotein physiology indicate improved lipid handling.
- Modulation of selected coagulation and fibrinolytic factors suggests an antithrombotic effect.
Conclusions:
- Fibrates demonstrate beneficial effects on multiple systems implicated in atherosclerosis.
- The combined actions on lipoproteins and hemostasis support fibrates' role in atherosclerosis prevention.
- Fibrates represent a valuable therapeutic option for managing cardiovascular risk.
Abstract:
The effects of fibrates on lipoprotein profiles and lipoprotein physiology, as well as on selected coagulation and fibrinolytic factors are reviewed. It is concluded that the action of fibrates on these systems is such as to render the fibrates beneficial in atherosclerosis prevention.