Hematologic disorders including sickle-cell syndromes, hemophilia, and beta-thalassemia

A review of the literature on rheumatologic manifestations in hematologic disease supports the idea that magnetic resonance imaging is useful in the identification of tissue patterns suggestive of vasoocclusion and myonecrosis in sickle-cell anemia and in diagnosing significant synovial hypertrophy in hemophilia. With reference to treatment, the use of yttrium-90 silicate and P-32 colloid for radiosynovectomy in patients with hemophilic arthropathy and the latest results of total joint replacement surgery in sickle-cell anemia and hemophilia patients are discussed.