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Comedonal Darier's disease

E K Derrick1, C R Darley, S Burge

  • 1Department of Dermatology, Brighton General Hospital, Elm Grove, U.K.

The British Journal of Dermatology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Darier's disease typically presents on the trunk. This report details two rare cases of Darier's disease exhibiting unusual nodular and comedonal facial and scalp lesions.

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Area of Science:

  • Dermatology
  • Genetics
  • Histopathology

Background:

  • Darier's disease is a rare, autosomal dominant genodermatosis.
  • It is characterized by specific clinical and histological features.

Observation:

  • Typical Darier's disease lesions affect the trunk and flexural areas.
  • This study presents two atypical cases with facial and scalp involvement.

Findings:

  • The observed cases displayed prominent nodular and comedonal lesions.
  • Histopathology confirmed acantholytic dyskeratosis, consistent with Darier's disease.

Implications:

  • Highlights the variable clinical presentation of Darier's disease.
  • Suggests considering Darier's disease in cases of unusual facial/scalp lesions.