Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Inflammatory cellular infiltration in scleritis]

W Bernauer1, B Daicker

  • 1Universitäts-Augenklinik Basel.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|February 1, 1995
PubMed
Summary

Scleritis involves T-cell mediated inflammation, suggesting an autoimmune basis for this destructive eye disease. Understanding these cellular mechanisms is crucial for effective treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid.

Journal of ophthalmic inflammation and infection·2018
Same author

Control of ocular disease in mucous membrane pemphigoid.

Klinische Monatsblatter fur Augenheilkunde·2014
Same author

Contact lens-associated fusarium keratitis in Switzerland.

Klinische Monatsblatter fur Augenheilkunde·2008
Same author

Phosphate concentration in ophthalmic corticoid preparations.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2008
Same author

Phosphate concentrations in antiglaucoma medication.

Klinische Monatsblatter fur Augenheilkunde·2007
Same author

[Chronic (kerato-) conjunctivitis refractory to therapy in children].

Klinische Monatsblatter fur Augenheilkunde·2006

Area of Science:

  • Ophthalmology
  • Immunology
  • Pathology

Background:

  • Scleritis is a destructive eye condition often linked to autoimmune disorders.
  • The precise cellular mechanisms driving scleritis pathogenesis remain poorly understood.
  • Primary vasculitis is suspected but requires further investigation into effector cells.

Observation:

  • Analysis of two enucleated eyes with scleritis (anterior necrotizing and posterior).
  • Morphological and immunohistochemical methods were employed to identify infiltrating cells.
  • T cells, particularly CD4-positive, were the predominant infiltrating cells in the sclera.

Findings:

  • T cells and B cells were identified within the scleral tissue.
  • Neutrophils, macrophages, and plasma cells were present in specific areas.
  • Necrotizing scleritis showed granulomatous inflammation with activated macrophages.
  • Major histocompatibility class II (MHC II) molecules were expressed on lymphocytes and some macrophages.
  • No evidence of primary vasculitis was observed in the studied specimens.

Implications:

  • The cellular infiltrate suggests scleritis may be a T-cell mediated autoimmune disorder.
  • Understanding these cellular mechanisms has significant implications for scleritis treatment.
  • Findings support the need for immunomodulatory therapies in managing scleritis.

Related Experiment Videos