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[Effect of sheng mai san on lipid peroxidation in acute myocardial infarction patients]
Insights
Sheng Mai San (SMS) may help prevent and treat coronary heart disease (CHD) by reducing lipid peroxidation damage. This traditional Chinese medicine acts as a free radical scavenger, improving antioxidant enzyme activity in patients.
Area of Science:
- Biochemistry
- Pharmacology
- Cardiology
Context:
- Coronary heart disease (CHD) is characterized by increased oxidative stress and lipid peroxidation.
- Patients with CHD exhibit reduced levels of antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px).
- Elevated levels of malondialdehyde (MDA), a marker of lipid peroxidation, are observed in CHD patients.
Purpose:
- To investigate the therapeutic effects of Sheng Mai San (SMS) on oxidative stress markers in patients with coronary heart disease (CHD).
- To evaluate SMS's impact on lipid peroxidation and antioxidant enzyme activity in acute myocardial infarction (AMI) patients.
Summary:
- Oral administration of SMS to 38 AMI patients significantly increased SOD and GSH-Px activities and decreased MDA levels.
- These beneficial effects were dose-dependent and more pronounced with prolonged SMS treatment (two weeks).
- A control group of 30 AMI patients not receiving SMS showed no significant changes in these oxidative stress markers.
Impact:
- The findings suggest that SMS acts as a potent free radical scavenger, mitigating lipid peroxidation damage in CHD.
- SMS demonstrates potential as an effective agent for both the prevention and treatment of coronary heart disease.
- This study supports the use of traditional Chinese medicine in managing cardiovascular conditions associated with oxidative stress.
Abstract:
The effect of Sheng Mai San (SMS) on the coronary heart disease (CHD) patients (30 angina pectoris and 68 acute myocardial infarction, AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood were decreased and the content of malondialdehyde (MDA) in plasma was increased in CHD patients in comparison with the healthy controls (P < 0.001). When SMS was orally administered in 38 AMI patients, both SOD and GSH-Px activities were increased and the level of MDA decreased (P < 0.05), and these changes were even more significant when SMS was further ingested for another two weeks (P < 0.001). At the same time, it was found that the changes of SOD, GSH-Px and MDA in the control group (30 AMI patients not taking SMS) were not significantly different (P > 0.05). It could be assumed that the pathogenesis of CHD is associated with free radical (FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effective free radical scavenger, which would ameliorate the lipid peroxidation damage. Thus, SMS could be administered in the prevention and the treatment of CHD.
