Related Experiment Videos
[Epidemiological study of blood stasis and plasma tissue plasminogen activator and its inhibitor activity in healthy
L D Liangmin1, L H Lu, X M Zhang
1Fujian Union Hospital, Fuzhou.
Insights
Blood stasis, a condition affecting over 50% of healthy older adults, increases with age. This study links higher tissue plasminogen activator (t-PA) levels in aging individuals to a compensatory mechanism against hypercoagulability.
Area of Science:
- Gerontology
- Hematology
- Physiology
Context:
- Blood stasis prevalence increases with age, affecting over 50% of healthy individuals in the presenile geriatric period.
- A significant age-dependent increase in blood stasis detectable rates was observed (P < 0.005).
Purpose:
- To investigate the prevalence of blood stasis in healthy aging individuals compared to young adults.
- To analyze plasma levels of tissue plasminogen activator (t-PA) and its inhibitor (PAI) in relation to aging and blood stasis.
Summary:
- The study found a higher prevalence of blood stasis in healthy older adults (51.79%) compared to younger individuals.
- Plasma t-PA activity was significantly elevated in the presenile geriatric group (P < 0.01), while PAI activity remained unchanged.
- The ratio of PAI to t-PA (P/t) was markedly decreased in older adults.
Impact:
- The findings suggest that elevated t-PA activity in aging is a physiological compensatory response to hypercoagulability.
- This compensatory mechanism plays a crucial role in maintaining hemostatic balance in the elderly.
- Understanding these age-related hemostatic changes can inform strategies for managing coagulation disorders in geriatric populations.
Abstract:
According to the blood stasis survey of 77 healthy subjects in presenile geriatric period, in comparison with 35 healthy young people, it was found the 51.79% of healthy subjects had blood stasis. The detectable rate were significantly different among various age groups (P < 0.005), and the rate increase was age-dependent. Chromogenic peptide substrate analytical method was used to detect plasma tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor (PAI) activity and ratio of P/t. The result revealed that the activity of plasma t-PA in presenile geriatric period subjects was significantly higher than that of young people (P < 0.01), but the activity of PAI had no difference in various age groups, and the ratio of P/t was markedly decreased. It showed that this was the physiological compensatory reaction of aging organism against hypercoagulability, and it was an effective way to maintain the physiological balance of the aged.