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An institutional review of sarcomas of the large and small intestine
J Horowitz1, J E Spellman, D L Driscoll
1Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Background:
This study was done to review the institutional experience with the treatment of sarcoma of the small or large intestine.
Study Design:
Thirty-nine patients admitted between the years 1959 and 1987, with a diagnosis of sarcoma of the small or large bowel form the basis of this review.
Results:
At referral, 74 percent of the patients presented with peritoneal sarcomatosis. Only six patients underwent complete resection. The overall five-year survival rate was 20 percent. Patients with low grade tumors had median and five-year survival rates of 33.3 months and 44 percent, respectively, while patients with high grade tumors had median and five-year survival rates of 22.4 months and zero percent, respectively, p = 0.01. Patients undergoing complete resection had a median survival period of 33.3 months, while patients receiving less than complete resection had a median survival period of 15.4 months, p = 0.003. Factors found to be significant by multifactorial analysis included tumor size, grade, stage at presentation, and invasion of adjacent organs.
Conclusions:
Sarcoma of the small and large bowel is an uncommon entity. Survival rates are relatively poor. Aggressive surgical intervention is the mainstay of therapy.