Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new localization method using an adiabatic pulse, BIR-4

R A de Graaf1, Y Luo, M Terpstra

  • 1Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis 55455.

Journal of Magnetic Resonance. Series B
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and manufacture of an ultra-compact, 1.5 T class, controlled-contact resistance, REBCO, brain imaging MRI magnet.

Superconductor science & technology·2024
Same author

Capturing fast relaxing spins with SWIFT adiabatic rotating frame spin-lattice relaxation (T1ρ) mapping.

NMR in biomedicine·2016
Same author

The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing.

Leukemia·2014
Same author

Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.

Neuroscience·2013
Same author

In vivo GABA T2 determination with J-refocused echo time extension at 7 T.

NMR in biomedicine·2013
Same author

Initial experience with seven tesla magnetic resonance spectroscopy of hypothalamic GABA during hyperinsulinemic euglycemia and hypoglycemia in healthy humans.

Magnetic resonance in medicine·2013
Same journal

NMR pulse schemes for the sequential assignment of arginine side-chain H epsilon protons.

Journal of magnetic resonance. Series B·1996
Same journal

In vivo imaging of nitroxide-free-radical clearance in the rat, using radiofrequency longitudinally detected ESR imaging.

Journal of magnetic resonance. Series B·1996
Same journal

Extracting quantitative information from two- and three-dimensional NOE spectra measured with short recycle delays.

Journal of magnetic resonance. Series B·1996
Same journal

HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in 13C/15N-labeled proteins.

Journal of magnetic resonance. Series B·1996
Same journal

A three-dimensional NMR imaging scheme utilizing doubly resonant gradient coils.

Journal of magnetic resonance. Series B·1996
Same journal

Observing N-acetyl aspartate via both its N-acetyl and its strongly coupled aspartate groups in in vivo proton magnetic resonance spectroscopy.

Journal of magnetic resonance. Series B·1996
See all related articles

A novel integrated outer-volume suppression-ISIS method achieves accurate localized spectroscopy using only three radiofrequency pulses. This technique excels even with strong signals and short relaxation times, enhancing magnetic resonance imaging capabilities.

Area of Science:

  • Magnetic Resonance Imaging
  • Spectroscopy
  • Medical Physics

Background:

  • Localized spectroscopy is crucial for in vivo metabolic analysis.
  • Existing methods like outer-volume suppression (OVS) and ISIS have limitations.
  • Achieving precise localization, especially with challenging signal characteristics, remains an area for improvement.

Purpose of the Study:

  • To introduce a new, efficient method for localized spectroscopy.
  • To demonstrate the advantages of the integrated OVS-ISIS technique.
  • To validate the accuracy and robustness of the proposed method.

Main Methods:

  • Development of the integrated outer-volume suppression-ISIS (OVS-ISIS) pulse sequence.
  • Utilizing adiabatic pulses, specifically BIR-4, for localization.

Related Experiment Videos

  • Employing computer simulations, experimental imaging, and in vivo 1H spectroscopy for validation.

    • Main Results:

    • The integrated OVS-ISIS method achieves high-quality localization with only three radiofrequency pulses.
    • Localization accuracy is maintained even in the presence of intense signals and short relaxation times.
    • Experimental data confirm the effectiveness of the method in computer simulations and in vivo measurements.

    Conclusions:

    • The integrated OVS-ISIS technique offers a superior approach to localized spectroscopy.
    • This method provides enhanced accuracy and efficiency compared to previous techniques.
    • The findings support the clinical utility of integrated OVS-ISIS for in vivo spectroscopy.