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Allergic gastroenteropathy in children

A Moon1, R E Kleinman

  • 1Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|January 1, 1995
PubMed
Summary

Infants and children with allergic gastroenteropathy can experience diverse symptoms, including diarrhea and malabsorption. Further research into the complex immunopathogenesis is needed for improved management of these food antigen-related gastrointestinal disorders.

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Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Allergy

Background:

  • Gastrointestinal disorders in infants and children can stem from immunopathologic reactions to food antigens.
  • These reactions manifest in various ways, impacting digestion and nutrient absorption.

Purpose of the Study:

  • To review the pathogenesis, symptoms, and treatment of food antigen-induced gastrointestinal disorders in pediatric populations.
  • To consolidate current understanding of allergic colitis, proctitis, eosinophilic gastroenteritis, and cow milk intolerance.

Main Methods:

  • Comprehensive literature review using MEDLINE database (1960-1993).
  • Keywords included allergic colitis, eosinophilic gastroenteritis, cow milk intolerance, protein-losing enteropathy, and malabsorption.
  • Inclusion of established pediatric gastrointestinal disease textbooks.

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Main Results:

  • Symptoms of allergic gastroenteropathy range from classic allergic reactions to complex syndromes.
  • These syndromes can include diarrhea, malabsorption, and protein-losing enteropathy.
  • The immunopathogenesis underlying these conditions is intricate and not fully elucidated.

Conclusions:

  • Understanding the evolving gastrointestinal mucosal system is key to managing these disorders.
  • Improved diagnostic and therapeutic strategies are anticipated with further research.
  • Better care for infants and children with allergic gastroenteropathy is a primary goal.