[Immunoelectronmicroscopic study of fibronectin in Kupffer's cell in rats with multiple organ failure]

This essay studied the content and distribution of Fibronectin (Fn) in Kupffer's cells in rats with multiple organ failure (MOF) with the immunoelectronmicroscopy technique. The results revealed that there was a significant increase in Fn level in plasma and the amount of immunogold particles in Kupffer's cells during the early stage, but the changes were not evident in the late stage. Our findings indicated that the changes in content of Fn was closely related to the function of MPS and might play an important role in the pathogenic mechanism of MOF.