Jove
Visualize
Contact Us

Related Experiment Videos

Imaging techniques in the diabetic foot

L G Newman1

  • 1Division of Endocrinology and Metabolism, Mount Sinai Medical Center, New York, New York, USA.

Clinics in Podiatric Medicine and Surgery
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid lowering does not improve endothelial function in subjects with poorly controlled diabetes.

Diabetes care·2001
Same author

Magnetic resonance imaging.

The New England journal of medicine·1993
Same author

Risk factors for amputation in diabetics.

Annals of internal medicine·1993
Same author

Leukocyte scanning with 111In is superior to magnetic resonance imaging in diagnosis of clinically unsuspected osteomyelitis in diabetic foot ulcers.

Diabetes care·1992
Same author

Effects of amlodipine on myocardial infarction, infarct expansion, and ventricular geometry in the rat.

American heart journal·1992
Same author

Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline.

JAMA·1991
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Diabetic foot ulcers often involve undetected osteomyelitis. Leukocyte scanning is more sensitive than other imaging for diagnosing this bone infection, guiding timely treatment.

Area of Science:

  • Infectious Diseases
  • Diabetic Complications
  • Diagnostic Imaging

Background:

  • Osteomyelitis is a common complication of diabetic foot ulcers, frequently undetected clinically.
  • Accurate diagnosis of osteomyelitis is crucial for effective treatment and limb salvage in diabetic patients.

Purpose of the Study:

  • To evaluate the diagnostic performance of leukocyte scanning compared to conventional imaging methods for osteomyelitis in diabetic foot ulcers.
  • To establish guidelines for the diagnosis and management of osteomyelitis in diabetic foot ulcers based on ulcer depth and diagnostic test sensitivity.

Main Methods:

  • Leukocyte scanning using indium oxyquinoline was compared with radiographs, bone scans, and MR imaging.
  • Ulcer depth and bone exposure were assessed.

Related Experiment Videos

  • Prevalence of osteomyelitis was determined in different ulcer categories.

    • Main Results:

    • Leukocyte scanning demonstrated higher sensitivity than radiographs, bone scans, and MR imaging in diagnosing osteomyelitis.
    • Osteomyelitis prevalence was 100% in ulcers exposing bone and 82% in moderately deep ulcers.
    • Radiographs are recommended for shallow ulcers, followed by leukocyte scans if negative.

    Conclusions:

    • Leukocyte scanning is a highly sensitive tool for diagnosing osteomyelitis in diabetic foot ulcers.
    • Prompt treatment for osteomyelitis is recommended for ulcers with bone exposure or significant depth.
    • Bone biopsy and culture are essential for guiding antibiotic therapy when feasible.