Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytostasis against self-antigens

L De Giorgi, A Matossian-Rogers, H Festenstein

    Clinical and Experimental Immunology
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Immune cells can target tumor cells and macrophages expressing specific antigens. The study reveals how immune responses, particularly involving the I region, influence cytostasis against self-antigens, impacting cancer and autoimmune disease research.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Severe diarrhea and the McKittrick and Wheelock syndrome.

    QJM : monthly journal of the Association of Physicians·2022
    Same author

    Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.

    Clinical and experimental immunology·2019
    Same author

    Thymosin-alpha 1 (Zadaxin) enhances the immunogenicity of an adjuvated pandemic H1N1v influenza vaccine (Focetria) in hemodialyzed patients: a pilot study.

    Vaccine·2011
    Same author

    Effects of alprostadil on blood rheology and nucleoside metabolism in patients affected with lower limb chronic ischaemia.

    Clinical hemorheology and microcirculation·2001
    Same author

    Anti-human immunodeficiency virus activity of a new immunosuppressant drug called stepronin.

    Transplantation proceedings·2000
    Same author

    Pharmacological preconditioning of ischemic heart disease by low-dose dipyridamole.

    International journal of cardiology·1996
    Same journal

    Could we discuss the molecular signature of immune dysregulation?

    Clinical and experimental immunology·2026
    Same journal

    The many faces of cytokine storm syndrome: immunopathogenic mechanisms and clinical implications for a better patient management.

    Clinical and experimental immunology·2026
    Same journal

    PD-1 Engagement and Circulating Th17 Effector Activity During Secukinumab Treatment in Plaque Psoriasis.

    Clinical and experimental immunology·2026
    Same journal

    Henoch-Schoenlein purpura (HSP) like lesions in IL12RB1 and IL12B defects - A multi-centric experience from India.

    Clinical and experimental immunology·2026
    Same journal

    Case Series on the Efficacy of Daratumumab in Treating Patients with Anti-Interferon-Gamma Autoantibodies.

    Clinical and experimental immunology·2026
    Same journal

    Deleterious germline CARD11 gain-of-function variants alter human B-cell and CD4+ T-cell differentiation and function.

    Clinical and experimental immunology·2026
    See all related articles

    Area of Science:

    • Immunology
    • Transplantation
    • Oncology

    Background:

    • Alloimmunization is a process where an organism's immune system is exposed to foreign antigens, leading to the development of immune responses.
    • The major histocompatibility complex (MHC) in mice, including the K and D ends and the I region, plays a crucial role in immune recognition and response.
    • Understanding immune cell interactions with self-antigens is vital for comprehending autoimmune diseases and cancer immune evasion.

    Purpose of the Study:

    • To investigate the specificity of effector cells generated through alloimmunization against specific MHC regions (K end, D end, I region).
    • To determine the relationship between immune incompatibility in different I region subregions and the resulting cytostatic activity against syngeneic targets.
    • To explore the potential implications of these findings for understanding neoplastic transformation and autoimmune pathology.

    Related Experiment Videos

    Main Methods:

    • Mice of the C57Bl/10 congenic series were alloimmunized against lymphocytes with defined incompatibilities in the K end, D end, or I regions of the MHC.
    • Effector cell activity was assessed by measuring cytostasis against tumor and macrophage targets bearing syngeneic K-end and D-end antigens.
    • Experiments involved varying the degree of incompatibility during immunization, specifically focusing on the I-B subregion and other I regions.

    Main Results:

    • Effector cells demonstrated cytostatic activity against tumor and macrophage targets expressing syngeneic K-end and D-end antigens.
    • Immune responses restricted to the I-B subregion resulted in cytostasis against K-end antigens, while broader I region incompatibility was needed for D-end antigen targeting.
    • Immunization with syngeneic tumor cells also induced cytostasis against self-antigens, including K-end antigens in some cases.

    Conclusions:

    • The study highlights the intricate specificity of immune responses generated by alloimmunization, demonstrating how incompatibilities in specific MHC regions dictate targeting of self-antigens.
    • These findings suggest a potential link between immune recognition of specific MHC antigens and the development or progression of neoplastic diseases and autoimmune conditions.
    • Further research into these immune mechanisms could offer insights into novel therapeutic strategies for cancer and autoimmune disorders.