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Related Experiment Videos

Evaluation of gallbladder function before and after gastrectomy using a double-isotope method

T Hamasaki1, Y Hamanaka, A Adachi

  • 1Second Department of Surgery, Yamaguchi University, School of Medicine, Japan.

Digestive Diseases and Sciences
|April 1, 1995
PubMed
Summary
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Partial distal gastrectomy for gastric cancer impairs gallbladder motor function due to altered stomach emptying and vagus nerve injury. This leads to gallbladder dysfunction post-surgery.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Nuclear Medicine

Background:

  • Partial distal gastrectomy (Billroth-I reconstruction) for gastric cancer can affect gastrointestinal motility.
  • Gallbladder motor function is closely linked to gastric emptying and duodenal stimulation.

Purpose of the Study:

  • To investigate gallbladder motor function after partial distal gastrectomy for gastric cancer.
  • To determine the relationship between gallbladder and stomach motor function post-surgery.

Main Methods:

  • Utilized a double-isotope method with [99mTc]PMT for biliary tract and [111In]DTPA for digestive tract tracers.
  • Measured gastric emptying half-time (GET1/2), volume emptied per minute (VOL/MIN), and gastric emptying duration (GED).
  • Assessed gallbladder emptying half-time (GBET1/2), bile retention rate (RR), and time lag for bile ejection (TL).

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Main Results:

  • Gastric emptying was accelerated (reduced GET1/2, increased VOL/MIN, shortened GED) post-gastrectomy.
  • Gallbladder emptying showed no significant change in GBET1/2, but increased RR and prolonged TL.
  • These changes indicate postoperative gallbladder dysfunction.

Conclusions:

  • Postoperative gallbladder dysfunction is attributed to altered duodenal stimulation and intraoperative vagus nerve injury.
  • Injury to the hepatic branch of the left vagus nerve during lymph node dissection is a key factor.
  • Altered gallbladder motor function impacts patients following gastric cancer surgery.